JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

2421118-05-8

C20H20Cl2N4O4

451.3

JKE-1716

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years