MRTX-EX185 是负载 GDP 的KRAS和KRAS(G12D)的有效抑制剂，对 KRAS(G12D) 的IC50值为 90 nM。MRTX-EX185 还结合 GDP 负载的HRAS。

MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC 50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS [1].

C33H33FN6O2

564.65

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years