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Tosylchloramide sodium trihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tosylchloramide sodium trihydrate图片
CAS NO:7080-50-4
包装:1 g
市场价:913元

产品介绍

产品描述

Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.

体外活性

After tosylchloramide treatment, Gram-positive growth is reduced by 95% to 100% , regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition[1].

体内活性

In the rat tissues, A dose-dependently significant DNA damage and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats[2]. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress[3]. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day[4].

Cas No.

7080-50-4

分子式

C7H10ClNNaO3S

分子量

246.67

别名

Tosylchloramide sodium trihydrate

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years