hCAI/II-IN-2 (compound 2b) 是一种有效的双重hCA I/II抑制剂，对于 hCA I、hCA II 和 hCAⅨ，Ki值分别为 40.97、15.15 和 61.88 nM。hCAI/II-IN-2 具有抗急性高原病 (AMS) 的低氧活性和低细胞活性。

hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with K i values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity [1].

hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells [1]. Cell Cytotoxicity Assay [1] Cell Line: Embryonic kidney (HEK293T) cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: Had no apparent cytotoxicity.

Animal Model: Male BLAB/c mice [1] Dosage: 400 mg/kg Administration: Oral administration; 14 days. Result: Prolonged the survival time of mice by 21.7% compared with the blank control group.

2480283-75-6

C12H12N4O5S2

356.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years