Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

1446322-66-2

C111H188N42O24S2

2559.1

TAT-cyclo-CLLFVY

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years