VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC 50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC 50 s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1]. Cell Viability Assay[1]Cell Line: A549, RPMI8226 cells Concentration: 3-fold serial dilutions with the highest concentration at 10 μM Incubation Time: 72 hours Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC 50 = 2.9 and 0.86 μM, respectively).

2630950-38-6

C24H26BN5O4S

491.37

VCP/p97 inhibitor-1;VCP/p97 inhibitor-1

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years