PF-06761281 (Compound 4a) 是一种有效的、具有口服活性的、部分选择性钠偶联柠檬酸转运蛋白 (NaCT/SLC13A5) 抑制剂,对 HEKNaCT、 HEKNaDC1和 HEKNaDC3的IC50值分别为 0.51, 13.2 和 14.1 μM。
产品描述
PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC 50 values of 0.51, 13.2 and 14.1 μM against HEK NaCT, HEK NaDC1 and HEK NaDC3, respectively [1].
体外活性
PF-06761281 (Compound 4a) inhibits citrate uptake with IC 50 values of 0.12, 0.21 and 0.74 μM in rat, mouse and human Heps [1].
Cas No.
1854061-19-0
分子式
C13H17NO6
分子量
283.28
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years