您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Pelecopan
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Pelecopan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2378380-49-3
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
Pelecopan (BCX9930) 是一种有效的、选择性的口服补体因子D抑制剂,IC50值为14.3 nM。Pelecopan 可靶向补体因子D以预防PNH中的血管内和血管外溶血,也可用于其他替代途径介导的疾病。

产品描述

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC 50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases [1] [2].

体外活性

BCX9930 has a potent, highly specific inhibitory activity for purified human factor D with an IC 50 value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC 50 of 28.1 nM. BCX9930 completely blocks hemolysis of PNH cells in vitro (with an IC 50 value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes. BCX9930 suppresses AP activity in rhesus monkeys ex vivo assays [1] [3].

Cas No.

2378380-49-3

分子式

C23H19FN2O4

分子量

406.41

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years