TES-1025 是一种有效且特异性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶 (ACMSD, IC50 = 13 nM) 抑制剂。
产品描述
TES-1025 is an effective and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (IC50: 13 nM).
体外活性
TES-1025 increases NAD+ levels in cellular systems[1].
体内活性
TES-1025 (0.5 mg/kg; i.v.) shows low blood clearance, with low volumes of distribution and half-lives of about 5.33 h, although the blood concentration of TES-1025 (5 mg/kg) is quantifiable for up to 8 h after oral administration. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h. The greater oral exposure of TES-1025 is AUC0-8h of 19 200 hong/mL and 36 600 hong/mL, respectively[1].
Cas No.
1883602-21-8
分子式
C18H13N3O3S2
分子量
383.44
别名
TES-1025
储存和溶解度
DMSO:95 mg/mL (247.76 mM),Need warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years