您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > TES-1025
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TES-1025
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TES-1025图片
CAS NO:1883602-21-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
TES-1025 是一种有效且特异性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶 (ACMSD, IC50 = 13 nM) 抑制剂。

产品描述

TES-1025 is an effective and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (IC50: 13 nM).

体外活性

TES-1025 increases NAD+ levels in cellular systems[1].

体内活性

TES-1025 (0.5 mg/kg; i.v.) shows low blood clearance, with low volumes of distribution and half-lives of about 5.33 h, although the blood concentration of TES-1025 (5 mg/kg) is quantifiable for up to 8 h after oral administration. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h. The greater oral exposure of TES-1025 is AUC0-8h of 19 200 hong/mL and 36 600 hong/mL, respectively[1].

Cas No.

1883602-21-8

分子式

C18H13N3O3S2

分子量

383.44

别名

TES-1025

储存和溶解度

DMSO:95 mg/mL (247.76 mM),Need warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years