PKM2 activator 2 是一种具有抗增殖作用的丙酮酸激酶M2(PKM2) 激活剂，AC50为 66 nM。PKM2 activator 2 可能具有抗肿瘤增殖作用，并缓解 Warburg 效应，因为PKM2激活可使细胞恢复正常糖酵解代谢状态。

PKM2 activator 2 is a pyruvate kinase M2 ( PKM2 ) activitor with an AC 50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells [1].

PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines [1]. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC 50 value of 66 nM in the luciferase-coupled assay [1].

1186660-06-9

C20H18F2N2O4S2

452.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years