BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-CL-Yne inhibits PAD1-4 with Kinact/KI values of 6,400, 3,600, 10,800, and 4,900 M-1min-1, respectively. It has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters.

2219324-71-5

C28H26ClN5O

483.99

BB-Cl-Yne

DMF:PBS (pH 7.2) (1:5):0.16 mg/mL
DMF:20 mg/mL
DMSO:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years