BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中，它可透过血脑屏障，并改善由p25 引起的神经退行性病变相关的记忆缺陷。

BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes

Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1].

1404562-17-9

C16H18N4O

282.34

BRD6688

ethanol:≤2mg/ml
DMSO:30mg/ml
dimethyl formamide:30mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years