DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

In vitro, DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.

13419-46-0

C5H7Cl2NO2S

216.09

DCVC

DMSO:23 mg/mL (106.44 mM)
H2O:1.034 mg/mL (4.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years