Desirudin (CGP 39393) 是一种凝血酶 (Thrombin) 抑制剂。Desirudin 可抑制血栓形成和静脉淤血性血栓形成，可用于血小板减少症或血小板功能障碍相关的研究。

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction [1] [2].

Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation [1]. Desirudin (0.01-1 mg/kg approximately, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED 50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED 50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.) [2]. Animal Model: Male mongrel dogs model of cardiopulmonary bypass [1] Dosage: 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h. Administration: Administered as a bolus plus infusion Result: Inhibits clot formation with no adverse hemodynamic or hematologic effects. Animal Model: Rat shunt model of thrombus formation on a cotton-thread [2] Dosage: 0.01-1 mg/kg approximately Administration: Intravenous injections, subcutaneous injection Result: Inhibited thrombus development with ED 50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.). Inhibited venous stasis thrombosis with ED 50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.).

120993-53-5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years