KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。

KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.

In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain[1].

796874-99-2

C20H25N3O2

339.439

KYP-2047

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years