Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) 是非选择性的，长效的钙离子通道 (Ca+channel) 拮抗剂，钠离子、钾离子通道 (Na+,K+channel) 抑制剂，具有抗心绞痛和抗 I 型心律失常作用。Bepridil hydrochloride hydrate 也是心脏 Na+/Ca2+交换 (NCX1) 抑制剂。Bepridil hydrochloride hydrate 可用于心血管疾病的研究。

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca + channel antagonist and Na +, K + channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na + /Ca2 + exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders [1] [2] [3] [4] [5].

Bepridil hydrochloride hydrate blockades of Ca 2+ -dependent action potentials in vascular smooth muscle of dog coronary artery [2]. Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC 50 s of 0.5 μM and 30 μM, respectively in cultured ventricular cells [4]. Bepridil hydrochloride hydrate decreases I Ks under blockade of I Kr with E4031 (5 μM), in a concentration-dependent manner [5].

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration [6].

74764-40-2

C24H37ClN2O2

421.02

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years