(R)-(+)-Bay K 8644 is a calcium channel inhibitor. It inhibits Ba2+ currents (IBa) (IC50: 975 nM).

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay K 8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay K 8644 inhibits Ba2+ currents (IBa) (IC50: 975 nM). When (R)-(+)-Bay K 8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay K 8644 (0.5 μM), an additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa.

98791-67-4

C16H15F3N2O4

356.3

(R)-(+)-Bay K 8644;(R)-(+)-Bay-K-8644

DMSO:300 mg/mL (841.98 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years