3-Hydroxykynurenine 是色氨酸的活性代谢物，可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。

3-Hydroxykynurenine is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.

In CD3/CD28 bead-stimulated CD4+ T cells, 3-Hydroxykynurenine (0-100 μM) dose-dependently inhibits CD4+ T-cell proliferation (IC50 = 70 μM). 3-Hydroxykynurenine (0-100 μM) dose-dependently induces significant CD4+ T-cell-mediated cell[3].

In BALB/c (H2d) mice, 3-Hydroxykynurenine (560 mg/kg; i.p.) significantly prolongs graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[3].

484-78-6

C10H12N2O4

224.21

DL-3-Hydroxykynurenine;3-hydroxy-DL-Kynurenine;3-Hydroxykynurenine

DMSO:1.4mg/mL (6mM),ultrasonic and warming and heat to 60°C
DMF:0.5 mg/mL
PBS (pH 7.2):0.5 mg/mL
Ethanol:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years