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Licochalcone A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Licochalcone A图片
CAS NO:58749-22-7
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)338.4
FormulaC21H22O4
CAS No.58749-22-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 67 mg/mL (198.0 mM)
Water: <1 mg/mL
Ethanol: 67 mg/mL (198.0 mM)
Other info

Chemical Name: (E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

InChi Key: KAZSKMJFUPEHHW-DHZHZOJOSA-N

InChi Code: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+

SMILES Code: O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC

Synonyms

Licochalcone-A

实验参考方法
In Vitro

In vitro activity: Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis.


Cell Assay: The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 μL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.

In VivoIn mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in> 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity.
Animal modelMice infected with L. major
Formulation & DosageDissolved in 20 uL of 99% (v/v) ethanol and suspended in 1% carboxymethyl cellulose (CMC) solution; 5mg/kg; Oral gavage or i.p. injection
References

Antimicrob Agents Chemother. 1993 Dec;37(12):2550-6; Antimicrob Agents Chemother. 1994 Jun;38(6):1339-44.