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BI 689648
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI 689648图片
CAS NO:1633009-87-6
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

体外活性

Compare with the FADs and LCI699, BI 689648 is highly selective in vitro, providing an IC50 for CYP11B2 of 2.1 nM and a selectivity factor of 149 over CYP11B1. FAD286, by comparison, shows a similar IC50 for CYP11B2 (2.5 nM). However, its greater potency against CYP11B1 (94 nM) results in a comparatively modest selectivity factor of 38, approximately 4-fold less than BI 689648[1].

体内活性

After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of ~500 nM. BI 689648 exhibits minimal impact on 11-DC and only at very high plasma concentrations (~10 μM)[1]. For BI 689648 (aldosterone EC50=2 nM), appreciable changes in 11-DOC are only noted at plasma concentrations >2000 nM or >1000-fold its aldosterone EC50 while FAD286 shows a window of ~100-fold.

Cas No.

1633009-87-6

分子式

C16H18N4O2

分子量

298.34

别名

BI 689648

储存和溶解度

DMSO:30 mg/mL (100.56 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years