TQS 是 α7 烟碱乙酰胆碱受体正变构调节剂,可用于神经炎性疼痛的研究。
产品描述
TQS is a positive allosteric modulator of α7 nACh receptors.
体内活性
TQS reduces LPS-induced IκB and CD11b gene expression and microglial activation associated with hyperalgesia and allodynia by targeting microglial α7 nAChR in the hippocampus[1].
Cas No.
353483-92-8
分子式
C22H20N2O2S
分子量
376.47
别名
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide;TQS
储存和溶解度
DMSO:240 mg/mL (637.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years