TKIM 是一种 TWIK 相关的钾通道 1 (TREK-1) 抑制剂，与 TREK-1 的中间 (IM) 状态的口袋结合。

TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.

TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.?Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.

326921-25-9

C18H14ClN3O2S

371.84

TKIM

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years