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Ravoxertinib hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ravoxertinib hydrochloride图片
CAS NO:2070009-58-2
包装:100 mg
市场价:10076元

产品名称
GDC-0994 (hydrochloride)
产品介绍

产品描述

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).

体外活性

Ravoxertinib inhibits p90RSK (IC50: 12 nM) [1]. Ravoxertinib is highly selective for ERK1 and ERK2 (biochemical potency: 1.1 nM and 0.3 nM, respectively) [2].

体内活性

Ravoxertinib (10 mg/kg; p.o.; in CD-1 mice) is sufficient to achieve the desired target coverage for at least 8 h [1]. Ravoxertinib (p.o.; daily) causes significant single-agent activity in multiple in vivo cancer models, including KRAS-mutant and BRAF-mutant human xenograft tumors in mice [2].

Cas No.

2070009-58-2

分子式

C21H19Cl2FN6O2

分子量

477.32

别名

GDC-0994 (hydrochloride);Ravoxertinib hydrochloride

储存和溶解度

DMSO:100 mg/mL (209.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years