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Hexestrol(HSDB 2149)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hexestrol(HSDB 2149)图片
CAS NO:84-16-2
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)270.37
FormulaC18H22O2
CAS No.84-16-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 42 mg/mL (155.3 mM)
Water: <1 mg/mL
Ethanol: 42 mg/mL (155.3 mM)
Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsHSDB 2149; Cycloestrol; Erythrohexestrol; HSDB2149; HSDB-2149; Hexoestrol; Sinestrol
实验参考方法
In Vitro

In vitro activity: Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen.

In VivoHexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.
Animal modelMice
Formulation & DosageDissolved in saline; 3 mg/kg and 6 mg/kg; i.p. injection
References

Eur J Med Chem. 2009 Sep;44(9):3412-24; Ann N Y Acad Sci. 2004 Dec;1028:247-57.