(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer . (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 μM).

161796-77-6

C17H19N3NaO3S

368.41

(R)-Omeprazole (sodium salt)

Ethanol:1 mg/mL
DMSO:5 mg/mL
PBS (pH 7.2):5 mg/mL
DMF:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years