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Dehydroepiandrosterone(DHEA)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dehydroepiandrosterone(DHEA)图片
CAS NO:53-43-0
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议
25g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)288.43
FormulaC19H28O2
CAS No.53-43-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 57 mg/mL (197.6 mM)
Water: <1 mg/mL
Ethanol: 57 mg/mL (197.6 mM)
Other info

Chemical Name: (3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one

InChi Key: FMGSKLZLMKYGDP-USOAJAOKSA-N

InChi Code: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

SMILES Code: C[C@]1([C@](CC2)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1)C2=O

Synonyms

NSC 9896; Prasterone; Psicosterone; DHEA; EL-10; GL-701; EL10; GL701; EL 10; GL 701; IP-1001; NSC-9896; IPL1001; NSC 896; IPL 1001; PB-007; SH-K-04828; Androstenolone; Diandrone;

实验参考方法
In Vitro

In vitro activity: Dehydroepiandrosterone reversibly blocks GABA-induced currents, behaving as an allosteric antagonist of the GABAA receptor in cultured neurons from ventral mesencephalon. Dehydroepiandrosterone (DHEA) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity, DHEAS also reduces NMDA-induced toxicity. DHEA (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. Dehydroepiandrosterone (DHEA) increases the length of neurites containing the axonal marker Tau-1 in primary cultures of mouse embryonic neocortical neurons, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion. Dehydroepiandrosterone (DHEA) rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone with H874Y stimulates a 3- to 8-fold greater response than with wild type AR and at 100 nM the response is similar with the LNCaP mutant in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.


Cell Assay: Treatment of T. crassiceps with DHEA decreasd reproduction, motility and viability in a dose- and time-dependent fashion. Moreover, Pre-treatment with DHEA (10–100 nM for 6–8 h) protected hippocampal neurons against excitatory amino acid (0.1, 1, 10, and 50 mM)-induced neurotoxicity in vitro.

In VivoDehydroepiandrosterone increases the number of newly formed cells in the dentate gyrus of the hippocampus of adult male rats, and also antagonizes the suppressive of corticosterone (40 mg/kg body weight daily for 5 days). Dehydroepiandrosterone by itself increases the number of newly formed neurons, but only if treatment is continued throughout the period of survival.
Animal modelOvarian cortical autograft (‘normograft’) model; or rats model
Formulation & DosageDHEA dissolved in sesame oil; single rod implants (length 5 cm, diameter 3.35 mm); s.c administration.
References

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1852-7; Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4678-83.