QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.

QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average< 10% of control amplitude. QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br-. QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death. QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner [1][3].

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli [2].

24003-58-5

C16H27BrN2O

343.3

QX-314 bromide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years