QO-40 是一种 KCNQ2/3 钾通道激活剂。

QO-40 is a KCNQ2/3 potassium channels activator.

QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?The compounds markedly slowed both KCNQ2/3 channel activation and deactivation kinetics.

1259536-70-3

C18H11ClF3N3O

377.75

QO-40

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years