Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是Sox2表达的有效抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,并限制脑动静脉畸形 (AVMs)。
产品描述
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias as well as limits the cerebral arteriovenous malformation (AVMs) [1] [2].
体外活性
Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces the expression of Sox2 to less than 10% after 2 days of treatment [2].
体内活性
Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation which limits cerebral arteriovenous malformation (AVMs) in Mgp –/– mice [2].
Cas No.
54-80-8
分子式
C15H19NO
分子量
229.32
别名
Pronetalol
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years