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Pronetalol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:54-80-8
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍
Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是Sox2表达的有效抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,并限制脑动静脉畸形 (AVMs)。

产品描述

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias as well as limits the cerebral arteriovenous malformation (AVMs) [1] [2].

体外活性

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces the expression of Sox2 to less than 10% after 2 days of treatment [2].

体内活性

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation which limits cerebral arteriovenous malformation (AVMs) in Mgp –/– mice [2].

Cas No.

54-80-8

分子式

C15H19NO

分子量

229.32

别名

Pronetalol

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years