Jedi2 是一种Piezo1活化剂，但不是 Piezo2 活化剂。Jedi2 以2770 μM的Kd值与小鼠 Piezo1 蛋白结合 。

Jedi2 is a Piezo1 activator rather than a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a K d of 2770 μM [1].

Jedi2 evokes Piezo1-mediated Ca 2+ influx. Jedi2 (200 μM) elicits dose-dependent responses specifically in mPiezo1-transfected cells while not in mPiezo2- or vector-transfected cells [1]. Jedi2 (1 mM) causes an increase in Ca 2+ in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM) [1].

651005-90-2

C10H8O3S

208.23

Compound Fr13138

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years