Dynole 2 24 是一种基于吲哚的Dynamin GTPase抑制剂 (对 Dynamin I的IC50=0.56 μM)。Dynole 2 24 无毒，在体外和细胞内显示出增强的抗动力蛋白I和II的效力 (IC (CME)=1.9 μM)。Dynole 2 24 对 Dynamin I的选择性为4.4倍。Dynole 2 24在网格蛋白介导的内吞作用的细胞抑制剂中具有活性。CME: Clathrin mediated endocytosis

Dynole 2 24 is an indole-based dynamin GTPase inhibitor ( IC 50 =0.56 μM for dynamin I). Dynole 2 24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC (CME) =1.9 μM). Dynole 2 24 also shows 4.4-fold selectivity for dynamin I. Dynole 2 24 is active in-cell inhibitor of clathrin-mediated endocytosis [1]. CME: Clathrin mediated endocytosis

1416313-72-8

C24H41N3

371.6

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years