产品描述
Fibronectin, a glycoprotein (~500 kDa) present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans.
体外活性
Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury. Increases in plasma Fibronectin (FN) has been reported after inflammation, trauma, and diseases such as atherosclerosis. Tobacco-related lung diseases are characterized by increased accumulation of Fibronectin (FN) which can be induced by nicotine. We found significant increases of plasma Fibronectin (FN) following exposure to e-cig aerosols and TS. Although our study examined the levels of 8-oxodG, CRP, and Fibronectin (FN), additional markers for lung injury need be explored in future studies[1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans)[2].
Cas No.
86088-83-7
别名
Fibronectin
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years