LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI 50 s of 0.68, 0.6, 16 and 0.14 μM, respectively[1]. LP-184 displays IC 50 s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay[1].

LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively[1]. Animal Model: Mice (MV522 tumors)[1]Dosage: 7.5 and 10 mg/kg Administration: I.p; 21day Result: Effective agent for human anti-tumor therapy.

924835-67-6

C16H20N2O4

304.346

LP-184

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years