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D8-MMAD
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D8-MMAD图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Monomethylauristatin D D8
Monomethyl Dolastatin 10 D8
Demethyldolastatin 10 D8
产品介绍

产品描述

D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.

体外活性

MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro.

体内活性

The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.

Cas No.

T10947

分子式

C41H58D8N6O6S

分子量

779.11

别名

Monomethylauristatin D D8;Monomethyl Dolastatin 10 D8;Demethyldolastatin 10 D8;D8-MMAD

储存和溶解度

DMSO:100 mg/mL (128.35 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years