FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury.

FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1. But it shows no effect on inducing ubiquitination of S1PR1 [1].

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI). It attenuates lung tissue leukocyte infiltration in bleomycin-injured mice [1].

402616-26-6

C19H34NO5P

387.45

(S)-FTY720P;(S)-FTY720 phosphate;FTY720 (S)-Phosphate

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years