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CB-6644
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CB-6644图片
CAS NO:2316817-88-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
CB-6644 是RUVBL1/2的选择性复合体抑制剂,能够抑制 RUVBL1/2 的 ATP 酶活性(IC50:15 nM)。它具有抗癌作用。

产品描述

CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).

体外活性

CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).

体内活性

CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

Cas No.

2316817-88-4

分子式

C29H34ClFN4O5

分子量

573.06

别名

CB-6644

储存和溶解度

DMSO:88 mg/mL (153.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years