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O-Propargyl-Puromycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-Propargyl-Puromycin图片
CAS NO:1416561-90-4
包装:10 mg
市场价:8726元

产品名称
O-Propargylpuromycin
产品介绍

产品描述

O-Propargyl-Puromycin is a potent inhibitor of protein synthesis.

体外活性

O-propargyl-puromycin (OP-puro).?OP-puro forms covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized or captured by copper(I)-catalyzed azide-alkyne cycloaddition.?Unlike methionine analogs, OP-puro does not require methionine-free conditions and, uniquely, can be used to label and assay nascent proteins in whole organisms.?This strategy should have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo

体内活性

In the small intestine, translation is strongest in cells in the crypts and at the base of intestinal villi, consistent with the high proliferative and secretory activity of these cells.?The stain is particularly strong in Paneth cells, which are located close to the base of the crypts and are filled with secretory vesicles.?The intense O-propargyl-puromycin labeling of vesicles in Paneth cells suggests that prematurely terminated, O-propargyl-puromycin-conjugated secretory proteins are translocated into the endoplasmic reticulum (ER) lumen[1].

Cas No.

1416561-90-4

分子式

C24H29N7O5

分子量

495.53

别名

O-Propargylpuromycin;O-Propargyl-Puromycin

储存和溶解度

DMSO:31 mg/mL (62.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years