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Cefoselis Sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefoselis Sulfate图片
CAS NO:122841-12-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品名称
FK 037 Sulfate
FK-037
硫酸头孢噻利
产品介绍
Cefoselis sulfate是一种头孢菌素 β-内酰胺抗生素。它对多种革兰氏阳性和革兰氏阴性生物均表现出良好的活性。它可以透过血脑屏障。

产品描述

Cefoselis is a widely used beta-lactam antibiotic.

体外活性

Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4]

体内活性

Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5]

Cas No.

122841-12-7

分子式

C19H22N8O6S2·H2SO4

分子量

620.64

别名

FK 037 Sulfate;FK-037;硫酸头孢噻利;Cefoselis Sulfate

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years