Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-Influenza Virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的SARS-CoV-2的抑制剂。

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir both suppresses virus propagation and modulates the expression of inflammatory cytokines and is used as an anti-influenza virus agent [3]. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2].

Umifenovir shows a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV [1].

Umifenovir (25 and 45 mg/ml; p.o.;) exhibits a survival benefit to mice suffering from influenza infection [3]. Animal Model: BALB/c mice (6–8 weeks old), mice were intranasally (i.n.) inoculated with 2 times the 50% mouse lethal dose (MLD 50 ) of A/ Guangdong/GIRD07/09 (H1N1) (10 4.5 TCID 50 /mL) in a volume of 20mL [3]. Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi) Administration: Oral administration Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.

131707-25-0

C22H25BrN2O3S

477.41

Arbidol

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years