Spermine Prodrug-1 (Compound 1) 是一种氧化还原敏感的精胺前药，可用于治疗 Snyder Robinson 综合征。Spermine Prodrug-1 抑制野生型 (CMS-24949) 和 精胺合酶基因 (SMS) 突变型 (CMS-26559, 和 CMS-6233) 成纤维细胞， IC50分别为 326.7, 198.5, 和 244.1 μM。

Spermine Prodrug-1 (Compound 1) is a redox-sensitive spermine prodrug for the potential treatment of snyder robinson syndrome. Spermine Prodrug-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC 50 s of 326.7, 198.5, and 244.1 μM, respectively [1].

2576358-68-2

C24H45Cl3N4O5

576

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years