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Fumagillin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fumagillin图片
CAS NO:23110-15-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
50 mg电议
100 mg电议

产品名称
烟曲霉素
NSC9168
Amebacilin
产品介绍
Fumagillin由烟曲霉菌中提取的一种抗菌药,有抗阿米巴活性。它通过抑制HIV-1 viral protein R活性来抑制HIV‐1感染。

产品描述

Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.

体外活性

Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4]

体内活性

In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2]

Cas No.

23110-15-8

分子式

C26H34O7

分子量

458.551

别名

烟曲霉素;NSC9168;Amebacilin;Fumagillin

储存和溶解度

DMSO:200.6 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years