ABX-464是一种抗HIV剂。它抑制受刺激的外周血单核细胞中的 HIV-1 复制,IC50值为 0.1 μM 至 0.5 μM。
产品描述
ABX-464 is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) (IC50 : 0.1 μM - 0.5 μM)
体内活性
ABX464 represents a novel class of anti-HIV molecules with unique properties. ABX464 has a long lasting effect in humanized mice and neutralizes the expression of HIV-1 proviral genome of infected immune cells including reservoirs and it is therefore a promising drug toward a functional cure of HIV[1].
Cas No.
1258453-75-6
分子式
C16H10ClF3N2O
分子量
338.71
别名
ABX-464;ABX464;Obefazimod
储存和溶解度
DMSO:100 mg/mL (295.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years