| CAS NO: | 72-33-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 310.43 |
|---|---|
| Formula | C21H26O2 |
| CAS No. | 72-33-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 15 mg/mL (48.3 mM) |
| Water: <1 mg/mL | |
| Ethanol: 25 mg/mL (80.5 mM) | |
| Other info | Chemical Name:
17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol InChi Key: IMSSROKUHAOUJS-UHFFFAOYSA-N InChi Code: InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3 SMILES Code: CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC |
| Synonyms | Ethinyl Estradiol 3 Methyl Ether; Devocin; Norquen; Ovastol; Ethynylestradiol 3-methyl ether; Ethinyl Estradiol 3-Methyl Ether |
| In Vitro | In vitro activity: Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized. |
|---|---|
| In Vivo | Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus. |
| Animal model | Rats |
| Formulation & Dosage | 0.02 mg/kg and 0.2 mg/kg diet |
| References | Carcinogenesis. 1996 Sep;17(9):2043-52; Brain Res Bull. 1988 Aug;21(2):329-33. |
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