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Bismuth Subcitrate Potassium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bismuth Subcitrate Potassium图片
CAS NO:880149-29-1
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
Bismuth subcitrate potassium 是针对 12 种幽门螺杆菌菌株的抗生素,MIC50为 8 μg/ml。它用于幽门螺杆菌感染的上胃肠道疾病的研究。

产品描述

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

体外活性

Colloidal Bismuth Subcitrate is crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer, the solubility of Colloidal Bismuth Subcitrate in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. [1] Bismuth Subcitrate is effective against the 12 C. pyloridis strains with MIC50 of 8 μg/mL. Bismuth Subcitrate combined with oxolinic acid exhibits synergistic activity against the 12 C. pyloridis strains. [2] Colloidal bismuth subcitrate (5 mg/mL) significantly increases the frequencies of sister-chromatid exchange (SCE) and micronucleus rate in peripheral lymphocytes compared with controls in human whole blood cultures. [3] Bismuth Subcitrate (100 μM) inhibits Helicobacter pyloriF1-ATPase activity, and inhibition is prevented and reversed by the mercaptan glutathione, indicating that Bismuth Subcitrate interfere with sulfhydryl groups of the enzyme. [4] Colloidal Bismuth Subcitrate (150 mg/mL) inhibits the lipolytic activity of C. pylori filtrate, causing a 21% reduction in lipase activity and a 60% reduction in the activity of phospholipase A. [5]

Cas No.

880149-29-1

分子式

C12H10BiK5O14

分子量

782.669

别名

Bismuth Subcitrate Potassium

储存和溶解度

H2O:127.8 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years