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PSI-7409 tetrasodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSI-7409 tetrasodium图片
CAS NO:1621884-22-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议

产品介绍

产品描述

PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977)(IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively).

体外活性

The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

Cas No.

1621884-22-7

分子式

C10H16FN2Na4O14P3

分子量

592.12

别名

PSI-7409 tetrasodium

储存和溶解度

H2O:125 mg/mL (211.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years