FR 167653 free base is an orally active p38 MAPK inhibitor and is effective in treating inflammation, relieving trauma, and ischemia-reperfusion injury in vivo. It also is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.

FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) obviously reduces the extent of acute tubular necrosis [1].

158876-65-4

C24H18FN5O2

427.43

FR 167653 free base

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years