Myr-ZIP is a cell-permeable inhibitor of the constitutively active protein kinase C (PKC) isoform PKMζ (Ki= 0.076-2.11 μM).1,2It also inhibits PKCα when used at a concentration of 10 μM.3Myr-ZIP (5 μM) prevents PKC translocation to the plasma membrane induced by ionomycin in HEK293 cells expressing A-kinase anchor protein 79 (AKAP79). Myr-ZIP inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0.5 μl per side.4

Myr-ZIP

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years