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(R)-Bicalutamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(R)-Bicalutamide图片
CAS NO:113299-40-4
包装:500 mg
市场价:22463元

产品介绍
(R)-Bicalutamide 是 Bicalutamide 的 R 型对映体。(R)-Bicalutamide 是一种雄激素受体 (AR) 拮抗剂,具有抗肿瘤活性。(R)-Bicalutamide 广泛用于前列腺癌的研究。

产品描述

(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer [1] [2].

体外活性

Bicalutamide is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer [1]. (R)-bicalutamide (0.02-20 μM) reduces na ve LNCaP cells survival in a dose-dependent manner [2]. Cell Proliferation Assay [2] Cell Line: LNCaP cells, LNCaP-Rbic cells Concentration: 0.02 μM, 0.2 μM, 2 μM, 20 μM Incubation Time: 144 hours Result: Reduced na ve LNCaP cells survival in a dose-dependent, with an IC 50 value of about 7 μM; exerted a poor antiproliferative effect on LNCaP-Rbic.

体内活性

(R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice [3]. Animal Model: CD1 male nude (nu/nu) mice, with VCaP xenografts [3] Dosage: 10 mg/kg Administration: Orally gavage, daily, for 4 consecutive weeks Result: Suppressed tumor growth.

Cas No.

113299-40-4

分子式

C18H14F4N2O4S

分子量

430.37

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years