MMP-9-IN-5 是一种MMP-9抑制剂 (IC50: 4.49 nM)，可与 MMP-9 形成氢键。MMP-9-IN-5 还抑制Akt活性 (IC50: 1.34 nM)。MMP-9-IN-5 具有细胞毒性并诱导细胞凋亡 (Apoptosis)。MMP-9-IN-5 可用于癌症研究。

MMP-9-IN-5 is a MMP-9 inhibitor ( IC 50 : 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity ( IC 50 : 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers [1].

MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells [1]. MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1]. MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1]. MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells [1]. Cell Viability Assay [1] Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells Concentration: 0-1 μM approximately Incubation Time: 72 h Result: Showed cytotoxicity with IC 50 s: 35.1 nM (Wi-38), 6.9 nM (MCF-7), 5.5 nM (NFS-60), 3.1 nM (HepG-2). Cell Migration Assay [1] Cell Line: HepG-2 Concentration: 3.1 nM Incubation Time: 24 h Result: Inhibited cell migration by 59.35%.

2581824-80-6

C27H20IN3O4

577.37

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years