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Pyridoxal isonicotinoyl hydrazone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyridoxal isonicotinoyl hydrazone图片
CAS NO:737-86-0
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议

产品名称
吡哆醛异烟酰肼
PIH
产品介绍
PyrIDOxal isonicotinoyl hydrazine 是亲脂的三价铁螯合剂,具有高铁螯合特性。

产品描述

Pyridoxal isonicotinoyl hydrazine is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo.

体外活性

After a 60-minute reincubation of 59Fe-labeled reticulocytes with tris-hydroxamate deferoxamine (5 mmol/L), 3.5% of cellular 59Fe was released, although Pyridoxal isonicotinoyl hydrazone (PIH) at a 50-fold lower concentration (0.1 mmol/L) released 38.6% of cellular 59Fe [1]. In primary human hepatocytes and the human hepatocellular carcinoma cell line HepG2/C3A, PIH treatment decreases Fech protein levels, but not Fech mRNA levels; and PIH is detected after isoniazid treatment, with levels increasing further when exogenous vitamin B6 analogs are coadministered [2].

体内活性

Intraperitoneal administration of PIH to mice (5 mg/25 gm mouse/day) over 6 days decreased 59Fe levels in the liver, spleen, and kidney but not in the blood. After oral administration, PIH resulted in an eightfold increase in fecal Fe excretion and possibly some urinary excretion of Fe [1].

Cas No.

737-86-0

分子式

C14H14N4O3

分子量

286.291

别名

吡哆醛异烟酰肼;PIH;pyridoxal isonicotinoyl hydrazone

储存和溶解度

DMSO:28.63 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years